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Helicobacter pylori infection and low serum pepsinogen I level as risk factors for gastric carcinoma

查看全文 作　　者：Arto [1]Kokkola;Johanna [1]Louhimo;Pauli [1]Puolakkainen;Henrik [2]Alfthan;Caj [1]Haglund;Hilpi [3]Rautelin 高影响力作者 机构地区：[1]Department of Surgery;[2]Department of Clinical Chemistry;[3]Department of Bacteriology and Immunology高影响力机构 出　　处：《World Journal of Gastroenterology》索引2005年第11卷第7期,共5页高影响力期刊 基　　金：Supported by the grant from the Helsinki University Central Hospital Research Funds (EVO) and Helsinki University's Research FundsWe thank Orion Diagnostica, Espoo, Finland, for kindly providing the Gastroset PGI test kits 摘　　要：AIM: To study whether examination of CagA antibodies could increase the odds ratio for gastric cancer in a casecontrol study, and how often other serum markers of gastric cancer risk could be found in Helicobacter pylorinegative patients.METHODS: H pylori CagA and parietal cell antibodies(PCAs), and serum pepsinogen Ⅰ (SPGI) levels were compared between patients with gastric cancer and controls who received endoscopic examination due to reasons other than gastrointestinal malignancy.RESULTS: The odds ratio (OR) for gastric cancer was2.9 (95% CI 1.4-5.8) in H pylori+ patients, and 2.4 (95%CI 1.2-4.9) in CagA+ patients. When results of H pylori and CagA antibodies were combined, OR increased to5.0 (95% CI 2.5-10.0). Furthermore, if cardia cancer patients were excluded, the OR increased to 6.8 (95% CI3.1-14.8). Among patients with a low SPGI level, the OR was 12.0 (95% CI 4.1-35.3). However, the risk was significant only in the older age group. The number of patients with low SPGI was significantly higher in H pylori-/CagA+ patients as compared to other cancer patients.CONCLUSION: Examination of both H pylori and CagA antibodies increases the OR for gastric cancer in our casecontrol study. CagA antibodies are important in detecting previous H pylori infection in advanced atrophic gastritis or cancer when spontaneous decline of H pylori antibodies occurs. SPGI may be helpful in screening elderly gastric cancer patients. 关 键 词：胃蛋白酶原I 胃癌 致病因素 CAGA 幽门螺杆菌
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