Positive association of RhoC gene overexpression with tumour invasion and lymphatic metastasis in gastric carcinoma

查看全文 作　　者：WANGZhen-[1]ning;XUHui-[2]mian;[1]JIANGLi;[2]ZHOUXin;[2]LUChong;[1]ZHANGXue

机构地区：[1]TheResearchCenterforMedicalGenomicsandMOHKeyLaboratoryofCellBiology,ChinaMedicalUniversity,Shenyang110001,China;[2]DepartmentofSurgicalOncology,theFirstHospitalofChinaMedicalUniversity,Shenyang110001,China

出　　处：《Chinese Medical Journal》索引2005年第6期,共3页

基　　金：ThisworkwassupportedbyNational973Program(No.G1998051203),NationalScienceFundforDistinguishedYong Scholars(No.30125017),andNationalNaturalScience FoundationofChina(No.30300342). 摘　　要：Worldwide estimates establish gastric carcinoma as the second most frequent cause of cancer deaths. Tumour invasion and metastasis is the biggest impediment to gastric carcinoma cure. Active migration of tumour cells is now considered as the pivotal step in cancer invasion and metastasis. RhoC is a member of the Ras-superfamily of small guanosine triphosphatases that can regulate many cellular functions, especially cytoskeletal organization and cell locomotion. Overexpressing RhoC in vitro in the poorly metastatic cell line from human melanoma may induce a highly metastatic phenotype.1 The recent development of laser capture microdissection (LCM) affords the opportunity to further evaluate the role RhoC plays in the invasion and metastasis of gastric carcinoma cells in their native tissue environment. 关键词：RHOC 基因表达胃癌淋巴腺肿瘤转移

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Positive association of RhoC gene overexpression with tumour invasion and lymphatic metastasis in gastric carcinoma

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