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Distribution of cysteinyl leukotriene receptor 2 in human traumatic brain injury and brain tumors

查看全文 作　　者：[1]HuaHU;[2]GaoCHEN;Jian-[2]minZHANG;Wei-[3]pingZHANG;[3]LeiZHANG;Qiu-[3]fuGE;Hong-[4]tianYAO;[4]WeiDING;[3]ZhongCHEN;Er-[3]qingWEI 高影响力作者 机构地区：[1]DepartmentofNeurosurgery,theSecondAffiliatedHospital,SchoolofMedicine,ZhejiangUniversity,Hangzhou310009//DepartmentofPharmacology,SchoolofMedicine,ZhejiangUniversity,Hangzhou310031;[2]DepartmentofNeurosurgery,theSecondAffiliatedHospital,SchoolofMedicine,ZhejiangUniversity,Hangzhou310009;[3]DepartmentofPharmacology,SchoolofMedicine,ZhejiangUniversity,Hangzhou310031;[4]DepartmentofPathology,theFirstAffiliatedHospital,SchoolofMedicine,ZhejiangUniversity,Hangzhou310003,China高影响力机构 出　　处：《Acta Pharmacologica Sinica》索引2005年第26卷第6期,共6页高影响力期刊 基　　金：Project supported by the National Natural Science Foundation of China (№ 30271498);the National Basic Research Program of China (№ G1999054000). 摘　　要：Aim: To determine the distribution of cysteinyl leukotriene receptor 2 (CysLT2),one of the cysteinyl leukotriene receptors, in human brains with traumatic injury and tumors. Methods: Brain specimens were obtained from patients who underwent brain surgery. CysLT2 in brain tissues was examined using immunohistochemical analysis. Results: CysLT2 was expressed in the smooth muscle cells (not in the endothelial cells) of arteries and veins. CysLT2 was also expressed in the granulocytes in both vessels and in the brain parenchyma. In addition, CysLT2 was detected in neuron- and glial-appearing cells in either the late stages of traumatic injury or in the area surrounding the tumors. Microvessels regenerated 8 d after trauma and CysLT2 expression was recorded in their endothelial cells.Conclusion: CysLT2 is distributed in vascular smooth muscle cells and granulocytes, and brain trauma and tumor can induce its expression in vascular endothelial cells and in a number of other cells. 关 键 词：颅脑损伤 脑肿瘤 半胱氨酰白三烯受体2 病理机制
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