Six-year follow-up of pancreatic β cell function in adults with latent autoimmune diabetes

查看全文 作　　者：[1]LinYang;Zhi-[1]GuangZhou;[1]GanHuang;Ling-[2]LiOuyang;[1]XiaLi;[1]XiangYan

机构地区：[1]InstituteofMetabolismandEndocrinology,theSecondXiangyaHospital,CentralSouthUniversity,Changsha410011,HunanProvince,China;[2]theFirstAffiliatedHospital,GuangxiMedicalUniversity,Nanning530021,GuangxiProvince,China

出　　处：《World Journal of Gastroenterology》索引2005年第11卷第19期,共6页

基　　金：Supported by the National Natural Science Foundation of China,No. 39370343 the National Ministry of Health Youth Talents Foundation, No. Q9420 the Hunan Health Bureau Key Scientific Funds, No. 9736, 2001-Z04 摘　　要：AIM: To investigate the characteristics of the progression of islet β cell function in Chinese latent autoimmune diabetes in adult (LADA) patients with glutamic acid decarboxylase antibody (GAD-Ab) positivity, and to explore the prognostic factors for β cell function. METHODS: Forty-five LADA patients with GAD-Ab positivity screened from phenotypic type 2 diabetic (T2DM) patients and 45 T2DM patients without GAD-Ab matched as controls were followed-up every 6 mo. Sixteen patients in LADA1 and T2DM1 groups respectively have been followed-up for 6 years, while 29 patients in LADA2 and T2DM2 groups respectively for only 1.5 years. GAD-Ab was determined by radioligand assay, and C-peptides (CP) by radioimmune assay.RESULTS: The percentage of patients whose fasting CP(FCP) decreased more than 50% compared with thebaseline reached to 25.0% at 1.5th year in LADA1 group, and FCP level decreased (395.8±71.5 vs 572.8±72.3 pmol/L, P<0.05) at 2.5th year and continuously went down to the end of follow-up. No significant changes of the above parameters were found in T2DM1 group. The average decreased percentages of FCP per year in LADA and T2DM patients were 15.8% (4.0-91.0%) and 5.2% (-3.5 to 35.5%, P= 0.000) respectively. The index of GAD-Ab was negatively correlated with the FCP in LADA patients (rs= -0.483, P = 0.000). The decreased percentage of FCP per year in LADA patients were correlated with GAD-Ab index, body mass index (BMI) and age at onset (rs = 0.408, -0.301 and -0.523 respectively, P<0.05). Moreover, GAD-Ab wasthe only risk factor for predicting βcell failure in LADA patients (B = 1.455, EXP (B) = 4.283, P = 0.023). CONCLUSION: The decreasing rate of islet β cell function in LADA, being highly heterogeneous, is three times that of T2DM patients. The titer of GAD-Ab is an important predictor for the progression of islet β cell function, and age at onset and BMI could also act as the predictors. 关键词：Β细胞胰腺细胞胰腺功能自身免疫糖尿病成年

相关文献

参考文献（31）
引证文献（5）
耦合文献（94）

参考文献(31)

引证文献(5)

耦合文献(94)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Six-year follow-up of pancreatic β cell function in adults with latent autoimmune diabetes

参考文献(31)

引证文献(5)

耦合文献(94)

用户提示