Acute exacerbation of autoimmune hepatitis induced by Twinrix

查看全文 作　　者：Antal [1]Csepregi;Gerhard [1]Treiber;Christoph R(o|¨)[1]cken;Peter [1]Malfertheiner

机构地区：[1]Department of Gastroenterology Hepatology, and Infectious Diseases, Department of Pathology, Otto-von-Guericke University, Leipziger Str. 44, Magdeburg 39120, Germany

出　　处：《World Journal of Gastroenterology》索引2005年第11卷第26期,共3页

摘　　要：We report on a 26-year-old man who presented with severe jaundice and elevated serum liver enzyme activities after having received a dose of Twinrix(○R). In his past medical history, jaundice or abnormal liver function tests were never recorded. Following admission, an elevated immunoglobulin G level and antinuclear antibodies at a titer of 320 with a homogenous pattern were found. Histology of a liver biopsy showed marked bridging liver fibrosis and a chronic inflammation, compatible with autoimmune hepatitis. Treatment was started with budesonide and ursodeoxycholic acid,and led to complete normalization of the pathological liver function tests. We believe that Twinrix(○R) led to an acute exacerbation of an unrecognized autoimmune hepatitis in our patient. The pathogenesis remains to be clarified. It is tempting to speculate that inactivated hepatitis A virus and/or recombinant surface antigen of the hepatitis B virus -as seen in patients with chronic hepatitis C and unrecognized autoimmune hepatitis who were treated with interferon alpha-might have been responsible for disease exacerbation. 关键词：自体免疫肝炎急性恶化药物诱导病理机制

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Acute exacerbation of autoimmune hepatitis induced by Twinrix

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