Focal nodular hyperplasia with concomitant hepatocellular carcinoma: a case report and clonal analysis

查看全文 作　　者：ZhangSH CongWM [1]WuMC 机构地区：[1]DepartmentofPathology,EasternHepatobiliarySurgeryHospital,SecondMilitaryMedicalUniversity,Shanghai200438,China 出　　处：《第二军医大学学报》索引2005年第26卷第7期,共1页 摘　　要：This report describes a hepatocellular carcinoma (HCC) with concomitant focal nodular hyperplasia (FNH) in a 56 years old Chinese man. There were two well circumscribed tumours measuring 3×2.5×2 cm and 2×1.5×1.5 cm. The larger mass was grey and soft with a small area of bleeding and necrosis and an intact capsule. The smaller mass was yellow and had no capsule. Clonal analysis was carried out to clarify the relation between the HCC and the adjacent FNH. The clonal analysis was based on the methylation pattern of the polymorphic X chromosome linked androgen receptor gene (HUMARA). In FNH, after Hpa Ⅱ digestion, the allelic bands showed two well defined peaks. The intensity of the two peaks in the DNA from cirrhotic tissue did not differ significantly, consistent with a random pattern of X chromosome inactivation. However, in HCC, after Hpa Ⅱ digestion, the allelic bands differed significantly in intensity. Therefore, there was a typical polyclonal pattern of inactivation in FNH but the HCC was interpreted as being monoclonal. 关 键 词：CASE Focal nodular hyperplasia with concomitant hepatocellular carcinoma a case report and clonal analysis