A family-based study of the association between the G72/G30 genes and schizophrenia in the Chinese population

查看全文 作　　者：[1]FanggengZou;[2]ChaoLi;[2]ShiweiDuan;[1]YonglanZheng;[3]NiufanGu;[3]GuoyinFeng;[4]YanglingXing;[4]JianguoShi;[1]LinHe 机构地区：[1]InstituteforNutritionalSciences,SIBS,ChineseAcademyofSciences,Shanghai200031,PRChina//Bio-XLifeScienceResearchCenter,ShanghaiJiaoTongUniversi.tv,Shanghai200030,PRChina;[2]Bio-XLifeScienceResearchCenter,ShanghaiJiaoTongUniversi.tv,Shanghai200030,PRChina;[3]ShanghaiInstituteofMentalHealth,600SouthWanPingRoad,Shanghai200030,PRChina;[4]Xi’anInstituteofMentalHealth,A7'an.PRChina 出　　处：《中国生物学文摘》索引2005年第19卷第6期,共5页 摘　　要：Studies have shown a strong positive association between schizophrenia and G72/G30, demonstrated by both individual markers and haplotypes. A further functional study also supports the role of G72 in the etiology of schizophrenia. In this study,we have replicated these results of transmission/disequilibrium testing (TDT) and haplotype analysis in the Han Chinese population, showing P values of 0.0018 and 0.00007 for individual markers and haplotypes, respectively. Hence, our datasupports the hypothesis that G72/G30 are important candidate genes for explaining schizophrenia in the Han Chinese population. 关 键 词：G72/G30基因 精神分裂症 单核苷酸碱基多态 单模标本 连锁不平衡 相关性 中国人种