Treatment of uncomplicated reflux disease

查看全文 作　　者：Joachim [1]Labenz;Peter [2]Malfertheiner

机构地区：[1]Department of Medicine Jung-Stilling Hospital Siegen,Germany;[2]Department of Gastroenterology Hepatology and Infectious Diseases,University of Magdeburg,Germany

出　　处：《World Journal of Gastroenterology》索引2005年第11卷第28期,共9页

摘　　要：Uncomplicated reflux disease comprises the non-erosive reflux disease (NERD) and erosive reflux disease (ERD).The objectives of treatment are the adequate control of symptoms with restoration of quality of life, healing of lesions and prevention of relapse. Treatment of NERD consists in the administration of proton pump inhibitors (PPI) for 2-4 wk, although patients with NERD show an overall poorer response to PPI treatment than patients with ERD owing to the fact that patients with NERD do not form a pathophysiologically homogenous group. For long-term management on-demand treatment with a PPI is probably the best option. In patients with ERD, therapy with a standard dose PPI for 4-8 wk is always recommended.Long-term treatment of ERD is applied either intermittently or as continuous maintenance treatment with an attempt to reduce the daily dosage of the PPI (step-down principle).In selected patients requiring long-term PPI treatment,antireflux surgery is an alternative option. In patients with troublesome reflux symptoms and without alarming features empirical PPI therapy is another option for initial management. Therapy should be withdrawn after initial success. In the case of relapse, the long-term care depends on a careful risk assessment and the response to PPI therapy. 关键词：逆流性疾病消化系疾病治疗方法质子泵抑制剂

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Treatment of uncomplicated reflux disease

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