Multidisciplinary approach to understand the pathogenesis of gastric cancer

查看全文 作　　者：Juan [1]Shang;AS Pe(n|~)[2]a

机构地区：[1]Hospital of Guangdong University of Technology;[2]Laboratory of Immunogenetics and Department of Gastroenterology

出　　处：《World Journal of Gastroenterology》索引2005年第11卷第27期,共9页

基　　金：Supported by the Foundation of Immunogenetics and Cluster I of VU University Medical Center, Amsterdam 摘　　要：Gastric carcinoma remains a common disease worldwide with a dismal prognosis. Therefore, it represents a very important health problem. It occurs with a high incidence in Asia and is one of the leading causes of cancer death in the world. Although the incidence and mortality of gastric carcinoma are decreasing in many countries,gastric cancer still represents the second most frequent malignancies in the world and the fourth in Europe. The 5-year survival rate of gastric carcinoma is low. The etiology and pathogenesis are not yet fully known. The study of gastric cancer is important in clinical medicine as well as in public health. Over the past 15 years,integrated research in molecular pathology has clarified the details of genetic and epigenetic abnormalities of cancer-related genes in the course of the development and progression of gastric cancer. Gastric cancer, as all cancers, is the end result of the interplay of many risk factors as well as protective factors. Although epidemiological evidence indicates that environmental factors play a major role in gastric carcinogenesis, the role of immunological, genetic, and immunogenetic factors are thought to contribute to the pathogenesis of gastric carcinoma. Among the environmental factors,diet and Helicobacter pylori are more amenable to intervention aimed at the prevention of gastric cancer.The aim of the present paper is to review and include the most recent published evidence to demonstrate that only a multidisciplinary approach will lead to the advancement of the pathogenesis and prevention of gastric cancer. On the immunogenetic research it is clear that evidence is accumulating to suggest that a genetic profile favoring the proinflammatory response increases the risk of gastric carcinoma. 关键词：发病机制胃癌疾病预后临床表现治疗方法

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Multidisciplinary approach to understand the pathogenesis of gastric cancer

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