Klatskin tumor treated by inter-disciplinary therapies including stereotactic radiotherapy: A case report

查看全文 作　　者：Gerhild [1]Becker;Felix [2]Momm;Henning [1]Schwacha;Norbert [2]Hodapp;Henning [1]Usadel;Michael [1]GeiBler;Annette [2]Barke;Annette Schmitt-Gr(a|¨)[3]ff;Karl [2]Henne;Hubert E. [1]Blum 机构地区：[1]Department of Medicine Ⅱ;[2]Department of Radiotherapy;[3]Institute of Pathology 出　　处：《World Journal of Gastroenterology》索引2005年第11卷第31期,共4页 摘　　要：In view of the poor prognosis of patients with cholangiocarcinoma (CCC), there is a need for new therapeutic strategies. Inter-disciplinary therapy seems to be most promising. Radiotherapy is an effective alternative to surgery for hilar CCC (Klatskin tumors) if an adequate radiation dose can be delivered to the liver hilus. Here,we describe a patient for whom we used a stereotactic radiotherapy technique in the context of an inter-disciplinary treatment concept. We report a 45-year-old patient with a locally advanced Klatskin tumor. Explorative laparotomy showed that the tumor was not resectable. A metallic stent was implanted and the patient was treated by stereotactic radiotherapy using a body frame. A total dose of 48 Gy (3x4 Gy/wk) was administered. Therapy was well tolerated. After 32 mo, local tumor recurrence and a chest wall metastasis developed and were controlled by radio-chemotherapy. After more than 56 mo with a good quality of life, the patient died of advanced neoplastic disease. Stereotactic radiotherapy led to a long-term survival of this patient with a locally advanced Klatskin tumor. In the context of inter-disciplinary treatment concepts, this radiotherapy technique is a promising choice of treatment for patients with hilar CCC. 关 键 词：放射治疗 病例报告 克拉斯汀瘤 胆管癌 病理机制