Time-dependent viscoelastic properties along rat small intestine

查看全文 作　　者：James B [1]Smith;Jing-Bo [2]Zhao;Yan-Ling [1,3]Dou;Hans [1,2]Gregersen

机构地区：[1]Institute of Experimental Clinical Research, Aarhus University, Denmark;[2]Center of Excellence in Visceral Biomechanics and Pain, Aalborg Hospital and Center of SMI, Aalborg University, Aalborg, Denmark;[3]Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China

出　　处：《World Journal of Gastroenterology》索引2005年第11卷第32期,共5页

基　　金：Supported by the Karen Elise Jensens Foundation and the Danish Technical Research Council 摘　　要：AIM: To measure the time-dependent (viscoelastic)behavior in the change of the small intestinal opening angle and to test how well the behavior could be described by the Kelvin model for a standard linear solid.METHODS: Segments from the duodenum, jejunum, and ileum were harvested from 10 female Wistar rats and the luminal diameter, wall thickness, and opening angleover time (θ(t)) were measured from rings cut from thesesegments.RESULTS: Morphometric variations were found along thesmall intestine with an increase in luminal area and adecrease in wall thickness from the duodenum to theileum. The opening angle obtained after 60 min washighest in the duodenum (220.8±12.9°) and decreasedalong the length of the intestine to 143.9±8.9° in the jejunum and 151.4±9.4° in the ileum. The change ofopening angle as a function of time, fitted well to theKelvin model using the equation θ(t)/θo = [1-ηexp (-λt)]after the ring was cut. The computed creep rate λ did notdiffer between the segments. Compared to constantcalculated from pig aorta and coronary artery, it showedthat α agreed well (within 5%), η was three times largerthan that for vascular tissue, and λ ranged ±40% from the value of the pig coronary artery and was a third of the value of pig aorta.CONCLUSION: The change of opening angle over timefor all the small intestine segments fits well to the standardlinear spring-dashpot model. This viscoelastic constantof the rat small intestine is fairly homogenous along itslength. The data obtained from this study add to a baseset of biomechanical data on the small intestine andprovide a reference state for comparison to other tissues,diseased intestinal tissue or intestinal tissue exposed todrugs or chemicals. 关键词：黏弹性道具小鼠动物模型治疗方法小肠疾病

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Time-dependent viscoelastic properties along rat small intestine

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