维普中文期刊产品整合服务

Relationship between genetic polymorphisms of alcohol and aldehyde dehydrogenases and esophageal squamous cell carcinoma risk in males

查看全文 作　　者：Chia-Fang [1]Wu;Deng-Chyang [1]Wu;Hon-Ki [2]Hsu;Ein-Long [3]Kao;Jang-Ming [4]Lee;Cheng-Chieh [5]Lin;Ming-Tsang [5]Wu 高影响力作者 机构地区：[1]Graduate Institute of Occupational Safety and Health and Department of Occupational Medicine Kaohsiung Medical University, Kaohsiung, Taiwan, China;[2]Department of Chest Surgery Kaohsiung Veterans General Hospital, Kaohsiung,Taiwan, China;[3]Department of Chest Surgery Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, China;[4]Department of Surgery National Taiwan University Hospital, Taipei, Taiwan, China;[5]Department of Family Medicine China Medical University and Hospital,Taichung 404,Taiwan, China高影响力机构 出　　处：《World Journal of Gastroenterology》索引2005年第11卷第33期,共6页高影响力期刊 基　　金：Supported by the Taiwan National Science Council, No. NSC 90-2320-B-037-040 and NSC 90-2320-B-037-052 the Taiwan National Health Research Institute, No. NHRI-CN-IN-9007P and NHRI-EX949428PI 摘　　要：AIM: To investigate the association between the genetic polymorphisms of ADH2 and ALDH2, lifetime alcohol consumption and esophageal cancer risk in the Taiwan Residents men.METHODS: Between August 2000 and June 2003, 134 pathologically-proven esophageal squamous cell carcinoma male patients and 237 male controls were recruited from Kaohsiung Medical University Hospital and Kaohsiung Veterans General Hospital in southern Taiwan.ADH2 and ALDH2 polymorphisms were genotyped using PCR-RFLP.RESULTS: Compared to those with ADH2*2/*2,individuals with ADH2*1/*2 and ADH2*1/*1 had 2.28-and 7.14-fold, respectively, increased risk of developing esophageal cancer (95%CI = 1.11-4.68 and 2.76-18.46)after adjusting for alcohol consumption and other covariates. The significant increased risk was also noted among subjects with ALDH2*1/*2 (adjusted OR (AOR)= 5.25, 95%CI = 2.47-11.19), when compared to those with ALDH2*1/*1. The increased risk of esophageal cancer was made greater, when subjects carried both ADH2*1/*1 and ALDH2*1/*2, compared to those with ADH2*1/*2 or ADH2*2/*2 and ALDH2*1/*1 (AOR = 36.79,95%CI = 9.36-144.65). Furthermore, we found a multiplicative effect of lifetime alcoholic consumption and genotypes (ADH2 and ALDH2) on esophageal cancer risk.CONCLUSION: Our findings suggest that polymorphisms of ADH2 and ALDH2 can modify the influence of alcoholic consumption on esophageal cancer risk. 关 键 词：遗传因素 基因多态性 酒精 乙醛脱氢酶 食管鳞状细胞癌
相关文献

参考文献(29)

引证文献(8)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费