Association of polymorphism of tumor necrosis factor-alpha gene promoter region with outcome of hepatitis B virus infection

查看全文 作　　者：Hong-Quan [1]Li;Zhuo [2]Li;Ying [1]Liu;Jun-Hong [2]Li;Jian-Qun [1]Dong;Ji-Rong [2]Gao;Chun-Yan [2]Gou;Hui [1]Li

机构地区：[1]Department of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences; School of Basic Medicine, Peking Union Medical College, Beijing 100005, China;[2]Institute of Hepatitis Research, Beijing You'an Hospital, Capital Medical University, Beijing 100005, China

出　　处：《World Journal of Gastroenterology》索引2005年第11卷第33期,共5页

基　　金：Supported by the Beijing Municipal Government Commission for Science and Technology, No. H020920020590 摘　　要：AIM: To determine whether -238G/A and -857C/T polymorphisms of tumor necrosis factor-alpha (TNF-α), gene promoter and hepatitis B (HB) viral genotypes were associated with outcomes of HBV infection.METHODS: A total of 244 HBV self-limited infected subjects, 208 asymptomatic carriers, and 443 chronic HB patients were recruited to conduct a case-control study.TNF-α -238G/A and -857C/T gene promoter polymorphisms were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and HBV genotypes were examined by nested PCR.RESULTS: The positive rate of HBV DNA in asymptomatic carrier group and chronic HB group was 46.6% and 49.9%,respectively. HBV genotype proportion among the asymptomatic carriers was 2.1% for genotype A, 25.8% for genotype B, 68.0% for genotype C, and 4.1% for genotype B+C mixed infection, and 0.9% for genotype A,21.7% for genotype B, 71.5% for genotype C, 5.9% for genotype B+C mixed infection in chronic HB group. There was no significant difference in genotype distribution between the asymptomatic carrier group and chronic HB group (x2 = 1.66, P = 0.647). The frequency of -238GG genotype in self-limited group was 95.1%, significantly higher than 90.7% in chronic HB group and 89.0% in asymptomatic carrier group (P = 0.041 and P = 0.016,respectively).The frequency of TNF-α-857 CC in chronic HB group was 79.7%, significantly higher than 64.4% in asymptomatic carrier group and 70.9% in self-limited group (P<0.001 and P = 0.023, respectively). A multiple logistic regression analysis revealed that TNF-α-238GA and -857CC were independently associated with chronic HB after gender and age were adjusted.CONCLUSION: TNF-α promoter variants are likely to play a substantial role in the outcome of HBV infection. 关键词：基因多态性肿瘤坏死因子-Α 乙型肝炎病毒病毒感染

相关文献

参考文献（18）
引证文献（19）
耦合文献（178）

参考文献(18)

引证文献(19)

耦合文献(178)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Association of polymorphism of tumor necrosis factor-alpha gene promoter region with outcome of hepatitis B virus infection

参考文献(18)

引证文献(19)

耦合文献(178)

用户提示