KL-6 mucin expression in carcinoma of the ampulla of Vater: Association with cancer progression

查看全文 作　　者：Wei [1]Tang;Yoshinori [2]Inagaki;Norihiro [1]Kokudo;Qian [1]Guo;Yasuji [1]Seyama;Munehiro [3]Nakata;Hiroshi [1]Imamura;Keiji [1]Sano;Yasuhiko [1]Sugawara;Masatoshi [1]Makuuchi

机构地区：[1]Hepato-Biliary-Pancreatic Surgery Division,Department of Surgery1Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo,IBunkyo-ku, Tokyo 113-8655, Japan;[2]Department of Applied Biochemistry, TokaiUniversity, Hiratsuka, Kanagawa 259-1292, Japan;[3]Department of Applied-Biochemistry andInstitute of Glycotechnology, Tokai University, Hiratsuka,Kanagawa 259-1292, Japan

出　　处：《World Journal of Gastroenterology》索引2005年第11卷第35期,共5页

基　　金：Supported by Grants-in-aid From the Ministry of Education, Science, Sports, and Culture of Japan and a grant for Hi-Tech Research from Tokai University 摘　　要：AIM: To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater.METHODS: Ampullary carcinoma tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection. Tissues were subjected to immunohistochemical analysis using KL-6 antibody.RESULTS: Positive staining of ampullary carcinoma cells was observed in 26 (68.4%) cases. Staining was not found in the surrounding non-cancer regions of the ampullary tissues. Remarkable KL-6 expression was observed in invasive carcinoma cells in pancreatic and duodenal tissues and in metastatic carcinoma cells in lymph nodes. Positive KL-6 expression was related to lymph node metastasis (P = 0.020), pancreatic invasion (P = 0.016), duodenal invasion (P = 0.034), and advanced stage of TNM clinical classification (P = 0.010). Survival analysis showed that positive expression of KL-6 was related to a poorer prognosis (P = 0.029).CONCLUSION: The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of carcinoma of the ampulla of Vater. 关键词：KL-6粘液素基因表达癌症疾病分类

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KL-6 mucin expression in carcinoma of the ampulla of Vater: Association with cancer progression

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