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Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions

查看全文 作　　者：Lin [1,5]LI;Hai Shan [3,6]LI;C. David [1,2,3]PAUZA;Michael [4]BUKRINSKY;Richard Y [1,2,3]ZHAO 高影响力作者 机构地区：[1]Department of Pathology,University of Maryland, Baltimore, MD 21201, USA;[2]Department of Microbiology-Immunology,University of Maryland, Baltimore, MD 21201, USA;[3]Institute of Human Virology, University of Maryland, Baltimore, MD 21201, USA;[4]Department of Microbiology, Immunology and Tropic Medicine, George Washington University, Washington, DC 20037,USA;[5]AIDS Research Department, Beijing Institute of Microbiology and Epidemiology, Bejing 100071, China;[6]National Center for AIDS, China Centers for Disease Control, Beijing 100050, China高影响力机构 出　　处：《Cell Research》索引2005年第15卷第11期,共12页高影响力期刊 摘　　要：Active host-pathogen interactions take place during infection of human immunodeficiency virus type 1 (HIV-1). Outcomes of these interactions determine the efficiency of viral infection and subsequent disease progression. HIV- infected cells respond to viral invasion with various defensive strategies such as innate, cellular and humoral immune antiviral mechanisms. On the other hand, the virus has also developed various offensive tactics to suppress these host cellular responses. Among many of the viral offensive strategies, HIV-1 viral auxiliary proteins (Tat, Rev, Nef, Vif, Vpr and Vpu) play important roles in the host-pathogen interaction and thus have significant impacts on the outcome of HIV infection. One of the best examples is the interaction of Vif with a host cytidine deaminase APOBEC3G. Although specific roles of other auxiliary proteins are not as well described as Vif-APOBEC3G interaction, it is the goal of this brief review to summarize some of the preliminary findings with the hope to stimulate further discussion and investiga- tion in this exhilarating area of research. 关 键 词：爱滋病病毒-1 辅助蛋白 病毒感染 中国 病原体
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