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Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study

查看全文 作　　者：Golo [1]Ahlenstiel;Agathe [1]Iwan;Jacob [1]Nattermann;Karin [1]Bueren;Jürgen K [1]Rockstroh;Hans H [2]Brackmann;Bernd [3]Kupfer;Olfert [4]Landt;Amnon [5]Peled;Tilman [1]Sauerbruch;Ulrich [1]Spengler;Rainer P [1]Woitas 高影响力作者 机构地区：[1]Department of Internal Medicine 1;[2]Institute of Experimental Hematology;[3]Institute of Medical Microbiology and Immunology;[4]TIB MOLBIOL Synthesis Laboratory;[5]Goldyne Savad Institute of Gene Therapy高影响力机构 出　　处：《World Journal of Gastroenterology》索引2005年第11卷第48期,共8页高影响力期刊 摘　　要：AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. 关 键 词：RANTES 基因多态性 爱滋病 丙型肝炎病毒
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