Therapeutic effect of DA-9601 on chronic reflux gastritis induced by sodium taurocholate in rats

查看全文 作　　者：Tae Young [1]Oh;Chang Yell [1]Shin;Yong Sung [1]Sohn;Dong Hwan [1]Kim;Byoung Ok [1]Ahn;Eun Bang [1]Lee;Cho Hyun [2]Park

机构地区：[1]Dong-A Pharmaceutical Research Institute,Yongin,Korea;[2]Department of General Surgery,Catholic University of Medicine,Seoul,Korea

出　　处：《World Journal of Gastroenterology》索引2005年第11卷第47期,共6页

基　　金：Supported by the grant from Korean Ministry of Health and Welfare, HMP-98-D-1-0007 摘　　要：AIM: To investigate the therapeutic effects of DA-9601 on sodium taurocholate (TCA)-induced chronic reflux gastritis in SD rats.METHODS: In this study, we have investigated the therapeutic effects of DA-9601 on chronic erosive and atrophic gastritis induced by 6 mo of TCA administration (5 mmol/L in drinking water) in SD rats. RESULTS: Four weeks of DA-9601 administration (0.065%, 0.216% in rat chow), following the withdrawal of TCA treatment, resulted in a significant decrease in total length of erosions in rats in a dose-dependent manner. Furthermore, the indicators of atrophic gastritis, such as reduced mucosal thickness and reduction in the number of parietal cells, were improved by the administration of DA-9601 in a dose-related manner. DA-9601 also attenuated inflammatory cell infiltration and the proliferation of collagenous fiber in the gastric mucosa. The improvement in the reduction of the gastric mucus was observed in the rats receiving a high dose of DA-9601 (0.216%). The therapeutic effect of DA-9601 on experimental chronic erosive gastritis was superior to that of rebamipide (1.08% in rat chow). Biochemical analyses showed increased mucosal prostaglandin E2 and reduced glutathione levels by DA-9601 treatment. CONCLUSION: We suggest that DA-9601 is apromising agent for the treatment of chronic erosive and atrophic gastritis with an etiological factor of bile reflux. Increasedmucosal prostaglandin E2 and reduced glutathione by DA-9601 treatment may be therapeutic mechanisms for chronic erosive and atrophic gastritis. 关键词：DA-9601 慢性胃炎牛磺胆酸钠治疗

相关文献

参考文献（34）
引证文献（6）
耦合文献（0）

参考文献(34)

引证文献(6)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Therapeutic effect of DA-9601 on chronic reflux gastritis induced by sodium taurocholate in rats

参考文献(34)

引证文献(6)

用户提示