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Steatosis recovery after treatment with a balanced sunflower or olive oil-based diet: Involvement of perisinusoidal stellate cells

查看全文 作　　者：Raquel [1]Hernández;Esther Martínez-[1]Lara;Ana Ca[1]uelo;Ma Luisa del [1]Moral;Santos [1]Blanco;Eva [1]Siles;Ana [1]Jiménez;Juan ngel [1]Pedrosa;Ma ngeles [1]Peinado 高影响力作者 机构地区：[1]Department of Experimental Biology,University of Jaén,Paraje Las Lagunillas s/n,E-23071 Jaén,Spain高影响力机构 出　　处：《World Journal of Gastroenterology》索引2005年第11卷第47期,共6页高影响力期刊 基　　金：Supported by Direction General de Investigation Cientifica y Tecnica, SAF 2003 04398-C02-02, and Junta de Andalucia,CVI-0184 摘　　要：AIM: To analyze the relationship between perisinusoidal stellate cell (PSC) activation and the dietary fat quantity and composition in the treatment of hepatic steatosis.METHODS: Using an experimental rat model of steatosis based on the intake of a hyperlipidic diet (14% fat as olive oil or sunflower oil, HL-O and HL-S, respectively), we analyzed the liver's capability of recovery after the treatment with a normal-lipidic diet (5% fat as olive oil or sunflower oil, NL-O and NL-S, respectively) by immunocytochemical and Western blot analysis of glial fibrillary acidic protein (GFAP) expression in PSCs, collagen quantification and serum aminotransferase determination.RESULTS: The fatty infiltration in the steatotic livers decreased after the treatment with both NL diets, indicating liver recovery. This decrease was accompanied with a lower collagen deposition and aminotransferase level as well as changes in the PSC population that increased the GFAP expression. The above-mentioned effects were more pronounced in animals fed on NL-O based diet. CONCLUSION: Treatment with a balanced dietenriched in olive oil contributes to the liver recovery from a stea totic process. The PSC phenotype is a marker of this hepatic-recovery model. 关 键 词：脂肪变性 橄榄油 星形细胞 治疗
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