Novel susceptibility genes in inflammatory bowel disease

查看全文 作　　者：Colin [1]Noble;Elaine [1]Nimmo;Daniel [1]Gaya;Richard K [1]Russell;Jack [1]Satsangi

机构地区：[1]Gastrointestinal Unit Molecular Medicine Centre,University of Edinburgh,Western General Hospital,Edinburgh,United Kingdom

出　　处：《World Journal of Gastroenterology》索引2006年第12卷第13期,共9页

摘　　要：The inflammatory bowel disease, Crohn's disease and ulcerative colitis, are polygenic disorders with important environmental interactions. To date, the most widely adopted approach to identifying susceptibility genes in complex diseases has involved genome wide linkage studies followed by studies of positional candidate genes in loci of interest. This review encompasses data from studies into novel candidate genes implicated in the pathogenesis of inflammatory bowel disease. Novel techniques to identify candidate genes-genome wide association studies, yeast-two hybrid screening, microarray gene expression studies and proteomic profiling, are also reviewed and their potential role in unravelling the pathogenesis of inflammatory bowel disease are discussed. 关键词：基因磁化肠炎病理机制治疗

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Novel susceptibility genes in inflammatory bowel disease

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