Preparation of Laminin-apatite-polymer Composites Using Metastable Calcium Phosphate Solutions

查看全文 作　　者：A [1]Oyane;M [2]Kasahara;N [2]Ichinose;Y [1]Yokoyama;M [3]Uchida;A [3]Ito 机构地区：[1]Nanotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST),Central 5, 1-1-1 Higashi, Tsukuba 305-8565, Japan;[2]School of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku 169-8555,Japan;[3]Institute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology (AIST),Central 6, 1-1-1 Higashi, Tsukuba 305-8566, Japan 出　　处：《Journal of Wuhan University of Technology(Materials Science)》索引2005年第20卷第B12期,共3页 基　　金：SupportedbyanIndustrialTechnologyResearchGrantProgramin2004fromtheNewEnergyandIndustrialTechnologyDevelopmentOrganization(NEDO)ofJapan. 摘　　要：A synthetic polymer with a laminin-apatite composite layer on its surface would be useful as a percutaneous device. The preparation of such a composite was attempted in the present study using poly(ethylene terephthalate) (PET) and polyethylene (PE) as the synthetic polymer. PET and PE plates and those pretreated with an oxygen plasma were alternately dipped in calcium and phosphate ion solutions, and then immersed in a metastable calcium phosphate solution supplemented with laminin (LCP solution). The PET and PE plates pretreated with an oxygen plasma formed a uniform and continuous layer of a laminin-apatite composite on their surfaces. In contrast, the PET and PE plates that had not been pretreated with an oxygen plasma did not form a continuous layer of a laminin-apatite composite on their surfaces. The hydrophilic functional groups on the PET and PE surfaces introduced by the plasma treatment were responsible for the successful laminin-apatite composite coating. 关 键 词：磷灰石 聚合体 磷酸钙 经皮肤操作装置 聚对苯二甲酸亚乙酯 聚乙烯