原发性胆汁性肝硬化:自身免疫性肝炎重叠综合征的长期预后和疗效

查看全文 作　　者：Chazouillères [1]O.;Wendum [1]D.;Serfaty [1]L.;赵菊辉(译)[2];尹勇(校)[2] 机构地区：[1]O. Chazouillères, Service d' Hépatologie, Hoepital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, France;[2]不详 出　　处：《世界核心医学期刊文摘(胃肠病学分册)》索引2006年第2卷第5期,共2页 摘　　要：Background/Aims: Whether primary biliary cirrhosis (PBC) autoimmune hepatitis (AIH) overlap syndrome requires immunosuppressive therapy in addition to ursodeoxycholic acid (UDCA) is a controversial issue. Methods: Seventeen patients with simultaneous form of strictly defined overlap were followed for 7.5 years. First-line treatment was UDCA alone (UDCA) in 11 and combination of immunosuppressors and UDCA (UDCA+ IS) in 6. Results: Characteristics at presentation were not significantly different between the 2 groups. In the UDCA+ IS group (f-up 7.3 years), biochemical response in terms of AIH features (ALT< 2ULN and IgG< 16 g/L) was achieved in 4/6 and fibrosis did not progress. In the UDCA group, biochemical response was observed in three patients together with stable or decreased fibrosis (f-up 4.5 years) whereas the eight others were non-responders with increased fibrosis in four (f-up 1.6 years). Seven of these eight patients subsequently received combined therapy for 3 years. Biochemical response was obtained in 6/7 and no further increase of fibrosis was demonstrated. Overall, fibrosis progression in non-cirrhotic patients occurred more frequently under UDCA monotherapy (4/8) than under combined therapy (0/6) (P=0.04). Conclusions: Combination of UDCA and immunosuppressors appears to be the best therapeutic option for strictly defined PBC-AIH overlap syndrome. 关 键 词：原发性胆汁性肝硬化 自身免疫性肝炎 重叠综合征 长期预后 UDCA治疗 肝纤维化程度 生化指标改变 免疫抑制剂 疗效 一线治疗