The Prognostic Significance of a Combined Determination of Cathepsin D and Estrogen Receptors in Breast Carcinomas with Positive Axillary Lymph Nodes

查看全文 作　　者：Yun Niu Xue Yang Yu Fan Ajuan Lu Tieju Liu Xilin [1]Fu 机构地区：[1]Department of Breast Pathology and Research, Tianjin Medical University Cancer Institute and Hospital, Tianjin 30006,China. 出　　处：《Chinese Journal of Clinical Oncology》索引2006年第3卷第3期,共5页 摘　　要：OBJECTIVE The aim of this study was to investigate the correlation be- tween cathepsin D (Cath-D) and estrogen receptor (ER)expression in breast cancer tissue and to explore the prognostic significance of their combined determination in breast carcinoma patients with positive axillary lymph nodes. METHODS One hundred and thirty-eight cases of breast carcinoma were examined by immunohistochemistry (IHC) and the results relating to patient follow-up analyzed. RESULTS The overall 5 -year disease -free survival rate (DFS) was 60.9% (84/138) in the series. The positive rate of Cath-D expression in the tumor cells was 55.07% and the positive ER staining was 51.4%. A definite significant negative correlation was found between the positive rates for Cath-D and ER (r=-0.294, P=0.001) The Cath-D expression for the cases in clinical Stage II, positive-node and recurrence or distant metastasis, was higher than that those cases in clinical Stage II with fewer node-metastasis and with 5 year DFS (χ2=13.926, P=0.000; χ2= 13.070, P=0.001; χ2=10.545, P=0.001). However, there was no signifi- cant difference of Cath-D expression between 2 groups of patients with different ages or among the different histopathologic types of the non- specific invasive carcinoma. In the combined examination of Cath-D and ER, the cases that were ER (+) and Cath-D (-) had the highest 5-year DFS compared to other situations. In contrast, the cases that were re- versed in expression , ie, ER(-) and Cath-D(+), had a lower 5-year DFS. There was a significant difference between the 2 conditions (χ2=18.675, P=0.000). CONCLUSION A combined determination and analysis of Cath-D and ER expression may be more useful to establish a prognosis than the bio- logical characteristics of carcinomas with positive lymph nodes. 关 键 词：组织蛋白酶D 疾病预防 雌激素 乳腺癌