硬化治疗可作为眼眶低血流性血管病变的一线疗法

查看全文 作　　者：Schwarcz R.M.;Ben Simon [1]G.J.;Cook T.;Goldberg R.A.;王静波 机构地区：[1]Royal Victorian Eye and Ear Hospital, 32 Gisborne St, East Melbourne, Vic. 3002, Australia Dr. 出　　处：《世界核心医学期刊文摘(眼科学分册)》索引2006年第2卷第5期,共1页 摘　　要：PURPOSE: To evaluate the outcome of sodium morrhuate 5%injections in patients with low flow vascular lesions, which consist of orbital lymphangiomas, and in one patient with intraosseous cavernous hemangioma. DESIGN: Pros-pective, interventional consecutive case series. METHODS: Intralesional sodium morrhuate 5%was injected under direct visualization or under radiographic guidance to six patients with orbital lymphangiomas and one patient with intraosseous cavernous hemangioma. Comprehensive eye examination and follow-up imaging studies were performed. MAINOUTCOME MEASURES: Lesion size was evaluated by orbital imaging and clinical examination, visual acuity, exophthalmos, and posttreatment complications. RESULTS: Seven patients (four female, three male; average age, 33 years) were included. Six patients were diagnosed with orbital lymphangioma, and one patient was diagnosed with intraosseous cavernous hemangioma. Patients received an average of 2.6 ±2 intralesional injections of sodium morrhuate, with a range of one to six injections and a mean volume of 0.9 ±0.8 ml (range, 0.2 to 2.1 ml). Lesions showed a decrease in size an average of 50%(33%) and ranged from minimal (10%) to near total resolution (85%). Visual acuity and intraocular pressure remained unchanged; exophthalmos decreased an average of 1.5 ±1.8 mm. Complications included one case of orbital hemorrhage that resolved spontaneously and transient keratopathy in all patients with anterior orbital lesions. CONCLUSION: Intralesional sclerosing therapy with sodium morrhuate 5%is effective in tumor debulking in patients with orbital lymphangioma and is not associated with vision-threatening complications. It may be a better alternative to surgery for low flow orbital tumors, which includes lymphangioma. 关 键 词：眼眶淋巴管瘤 血管病变 低血流 硬化治疗 5%鱼肝油酸钠 线疗法 海绵状血管瘤 病灶内注射 影像学研究 平均年龄