选择性5-羟色胺再吸收抑制剂与新生儿持续性肺动脉高压患病风险

查看全文 作　　者：Chambers C. [1]D.;Hernandez-Diaz [2]S.;Van Marter [2]L.J.;任付先(译)[2];马超(校)[2] 机构地区：[1]University of California, San Diego, Medical Center, Mail Code 8446, 200 W. Arbor Dr., San Diego, CA 92103, United States;[2]不详 出　　处：《世界核心医学期刊文摘(心脏病学分册)》索引2006年第2卷第6期,共2页 摘　　要：Background: Persistent pulmonary hypertension of the newborn(PPHN) is associated with substantial infant mortality and morbidity. A previous cohort study suggested a possible association between maternal use of the selective serotonin- reuptake inhibitor(SSRI) fluoxetine late in the third trimester of pregnancy and the risk of PPHN in the infant. We performed a case- control study to assess whether PPHN is associated with exposure to SSRIs during late pregnancy. Methods: Between 1998 and 2003, we enrolled 377 women whose infants had PPHN and 836 matched control women and their infants. Maternal interviews were conducted by nurses, who were blinded to the study hypothesis, regarding medication use in pregnancy and potential confounders, including demographic variables and health history. Results: Fourteen infants with PPHN had been exposed to an SSRI after the completion of the 20th week of gestation, as compared with six control infants(adjusted odds ratio, 6.1; 95 percent confidence interval, 2.2 to 16.8). In contrast, neither the use of SSRIs before the 20th week of gestation nor the use of non- SSRI antidepressant drugs at any time during pregnancy was associated with an increased risk of PPHN. Conclusions: These data support an association between the maternal use of SSRIs in late pregnancy and PPHN in the offspring; further study of this association is warranted. These findings should be taken into account in decisions as to whether to continue the use of SSRIs during pregnancy. 关 键 词：5-羟色胺再吸收抑制剂 持续性肺动脉高压 患病风险 新生儿 病例对照研究 SSRI类 PPHN 妊娠晚期 人口统计学 队列研究