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Prevalence of autoantibodies and the risk of autoimmune thyroid disease in children with chronic hepatitis C virus infection treated with interferon-α

查看全文 作　　者：Stephan [1]Gehring;Ulrike [2]Kullmer;Sabine [2]Koeppelmann;Patrick [3]Gerner;Philip [3]Wintermeyer;Stefan [3]Wirth 高影响力作者 机构地区：[1]The Liver Research Center, Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, Rhode Island, USA and Kinderklinik der Johannes-Gutenberg-Universitt, Mainz, Germany;[2]Kinderklinik der Johannes-Gutenberg-Universitt, Mainz, Germany;[3]Zentrum für Kinder-und Jugendmedizin, HELIOS Klinikum, Wuppertal, Witten-Herdecke-University, Germany高影响力机构 出　　处：《World Journal of Gastroenterology》索引2006年第12卷第36期,共6页高影响力期刊 摘　　要：AIM: To evaluate the prevalence of autoantibodies in chronic hepatitis C virus (HCV)-infected children focusing on thyroid autoimmunity. METHODS: We investigated the prevalence of auto- antibodies in 123 chronic HCV-infected children before, during and after monotherapy with interferon-alpha (IFN-α) or combined treatment with interferon-α or peginterferon-α and ribavirin. Besides antibodies against smooth muscle (SMA), nuclei (ANA), and liver/kidney microsomes (LKM), the incidence of anti- thyroid peroxidase antibodies as well as thyroid function parameters (TSH, FT3 and FT4) were determined. RESULTS: We found that 8% of children had autoantibodies before treatment. During treatment, 18% of children were found positive for at least one autoantibody; 15.5% of children developed pathologic thyroid values during IFN-α treatment compared to only one child before therapy. Six children had to be substituted while developing laboratory signs of hypothyroidism. CONCLUSION: Our data indicate a strong correlation between interferon-α treatment and autoimmune phenomena, notably the emergence of thyroid antibodies. The fact that some children required hormone replacement underlines the need of close monitoring in particularly those who respond to therapy and have to be treated for more than 6 mo. 关 键 词：自身抗体 甲状腺疾病 自身免疫 慢性丙性肝炎
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