Hepatic progenitor cells in human liver tumor development

查看全文 作　　者：Louis [1]Libbrecht

机构地区：[1]Liver Research Unit of the Laboratory of Morphology and Molecular Pathology, University of Leuven, Leuven, Belgium

出　　处：《World Journal of Gastroenterology》索引2006年第12卷第39期,共5页

摘　　要：In recent years, the results of several studies suggest that human liver tumors can be derived from hepatic progenitor cells rather than from mature cell types. The available data indeed strongly suggest that most combined hepatocellular-cholangiocarcinomas arise from hepatic progenitor cells that retained their potential to differentiate into the hepatocytic and biliary lineages. Hepatic progenitor cells could also be the basis for some hepatocellular carcinomas and hepatocellular adenomas, although it is very difficult to determine the origin of an individual hepatocellular carcinoma. There is currently not enough data to make statements regarding a hepatic progenitor cell origin of cholangiocarcinoma. The presence of hepatic progenitor cell markers and the presence and extent of the cholangiocellular component are factors that are related to the prognosis of hepatocellular carcinomas and combined hepatocellular- cholangiocarcinomas, respectively. 关键词：肝肿瘤病理机制肿瘤细胞治疗

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Hepatic progenitor cells in human liver tumor development

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