Hepatitis B virus genotypes in chronic liver disease patients from New Delhi,India

查看全文 作　　者：Saket [1]Chattopadhyay;Bhudev Chandra [2]Das;Premashis [1]Kar

机构地区：[1]PCR-Hepatitis labora-tory,Department of Medicine,Maulana Azad Medical College New Delhi-110002,India;[2]Institute of Cytology and preventive Oncology,(ICMR),Noida-201301,U.P,India

出　　处：《World Journal of Gastroenterology》索引2006年第12卷第41期,共5页

基　　金：Indian Council of Medical Research (ICMR)Government of India-funded Individual research project 摘　　要：AIM: To study the Hepatitis B virus (HBV) genotypes and their effect on the progression and outcome in patients with chronic liver diseases from New Delhi, India. METHODS: Sera from 100 HBV-related chronic liver disease (CLDB) cases were tested for HBV genotype using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and Type-specific primers-based PCR (TSP-PCR) targeting to the surface (S) gene encoding hepatitis B surface antigen. RESULTS: Only genotypes A and D were present and genotype D was dominant. Genotype D was present in all CLDB patient categories. The genotype distribution for the 100 patients with CLDB was as follows: genotype A, 16/100 (16%) (7/40- 17% chronic hepatitis B (CHB); 8/47, 17%, HBV-related cirrhosis (CRB); 1/13, 7.6%, HBV-related hepatocellular carcinoma (HCCB); genotype D- 84/100 (84%) (32/40- 80% CHB; 38/47- 81%, CRB; 11/13, 85%, HCCB); genotype A + D, 3/100 (3%) (1/40- 3% CHB; 1/47- 2%, CRB; 1/13, 7.6%, HCCB); C, 0; B, 0; E, 0; F, 0; G 0, H 0; (P < 0.01, genotype D vs A). CONCLUSION: Only HBV genotypes A and D were present in patients with CLDB from New Delhi, India. Compared with genotype D, genotype A patients had no significant clinical or biochemical differences (P > 0.05). Mixed infection with genotype A and D were seen in 3% of the cases. Genotype D was the dominant genotype prevalent in all patient categories. 关键词：乙型病毒肝炎病理治疗临床

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Hepatitis B virus genotypes in chronic liver disease patients from New Delhi,India

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