A case of interstitial pneumonitis in a patient with ulcerative colitis treated with azathioprine

查看全文 作　　者：Ferenc [1]Nagy;Tamas [1]Molnar;Eva [2]Makula;Ildiko [2]Kiss;Peter [2]Milassin;Eva [3]Zollei;Laszlo [4]Tiszlavicz;Janos [1]Lonovics

机构地区：[1]First Department of Medicine, University of Szeged, Faculty of Medicine, Szeged, Hungary;[2]Department of Radiology, University of Szeged, Faculty of Medicine, Szeged, Hungary;[3]Medical Intensive Care Unit, University of Szeged, Faculty of Medicine, Szeged, Hungary;[4]Institute of Pathology, University of Szeged, Faculty of Medicine, Szeged, Hungary

出　　处：《World Journal of Gastroenterology》索引2007年第13卷第2期,共4页

摘　　要：The early hypersensitivity reaction and late bone marrow depression are well-known side-effects of azathioprine, whereas interstitial pneumonia is a rare complication. A 40-year old male patient had been treated with azathioprine in consequence of extensive ulcerative colitis for 10 years. He then complained of 7 d of fever, cough and catarrhal signs, without symptoms of active colitis. Opportunistic infections were ruled out. The chest X-ray, CT and lung biopsy demonstrated the presence of interstitial inflammation. Azathioprine therapy was discontinued as a potential source of the pulmonary infiltrate. In response to steroid therapy, and intensive care, the pulmonary infiltrate gradually decreased within 4 wk. Three months later, his ulcerative colitis relapsed, and ileo-anal pouch surgery was performed. In cases of atypical pneumonia, without a proven infection, azathioprine-associated interstitial pneumonitis may be present, which heals after withdrawal of the drug. 关键词：肺炎大肠炎咪唑硫嘌呤免疫抑制剂

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A case of interstitial pneumonitis in a patient with ulcerative colitis treated with azathioprine

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