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Application of sentinel lymph node (SLN) biopsy in breast cancer patients

查看全文 作　　者：Tao [1]Zhang;Baoning [2]Zhang;Hong [1]Wang;Baoping [1]Chen;Xiliang [1]Wei;Ying [1]Fu;Lin [3]Liu;[4]HongyingYang;Shengzu [3]Ghen 高影响力作者 机构地区：[1]Department of Oncology Surgery, Affiliated Hospital of Hebei University, Baoding 071000, China;[2]Department of Abdomen Surgery, Cancer Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China;[3]Department of Nuclear Medicine, Cancer Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China;[4]Department of Pathology, Cancer Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China高影响力机构 出　　处：《The Chinese-German Journal of Clinical Oncology》索引2007年第6卷第1期,共3页高影响力期刊 摘　　要：Objective: To discuss if the sentinel lymph node (SLN) biopsy is able to reflect the status of the axillary lymph node and the application of this technic in clinic. Methods: Using 99mTc-signed dextran, SLN-biopsy (SLNB) was carried out in 182 cases with breast cancer during May 1999 to September 2006. During the operation, γ-detector was used for orientation. After the SLNB, a modified radical mastectomy or breast conserving surgery were carried out to the patients, then a particular separate pathological examination of the SLN was made. Results: 178 cases of SLNB were carried out successfully, and the success rate was 97.8%, the out-checked SLN of each case ranged from 1 to 4, with an average of 2.5. All SLN was located at the first level of axilla, sensitivity of the SLNB was 93.4%, specificity was 100%, false negative rate was 6.6%, false positive rate was 0, accuracy was 97.8%, positive predictive value was 100.0%, negative predictive value was 96.7%, and Youden’s index was 0.934. Immunohistochemical examination was carried out in 59 cases of SLN, and 14 cases showed the existences of micro-metastasis, however, metastasis had not been found in non-SLN of these cases. Conclusion: SLN is able to reflect the metastasis of the axillary lymph node, and this can suggest the necessity of the axillary dissection in clinic. The SLNB using the isotope-tracer technic is simple and accurate. 关 键 词：乳腺癌 前哨淋巴结活检 应用 放射性核素成像
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