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Cyclic vomiting syndrome in children: Experience with 181 cases from southern Iran

查看全文 作　　者：Mahmood [1]Haghighat;Seyed Mohammad [2]Rafie;Seyed Mohsen [3]Dehghani;Gholam Hossein [4]Fallahi;Marzieh [5]Nejabat 高影响力作者 机构地区：[1]Department of Pediatric Gastroenterology/Gastroenterohepatology Research Center of Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran;[2]Department of Pediatric Neurology, Shiraz University of Medical Sciences, Shiraz, Iran;[3]Department of Pediatric Gastro-enterology/Gastroenterohepatology Research Center of Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran;[4]Department of Pediatric Gastro-enterology, Tehran University of Medical Sciences, Tehran, Iran;[5]Department of Pediatric Gastroenterology, Shiraz University of Medical Sciences, Shiraz, Iran高影响力机构 出　　处：《World Journal of Gastroenterology》索引2007年第13卷第12期,共4页高影响力期刊 摘　　要：AIM: To evaluate the clinical presentation, response to prophylactic therapy and outcome of children with cyclic vomiting syndrome (CVS) in Shiraz, Iran.METHODS: During a period of 11 years (March 1994 to March 2005), 181 consecutive children with a final diagnosis of CVS were evaluated, treated and followed in our center. Patients were randomized to receive either amitriptyline or propranolol as prophylactic treatments. RESULTS: There were 88 boys and 93 girls with mean age of onset of symptoms of 4.9 ± 3.3 years (range, neonatal period to 14 years), the mean age at final diagnosis was 6.9 years (range, 1.5 to 14), and the mean duration between the onset of the first attack and the final diagnosis of CVS was 2 ± 1.81 years (range, 1/6 to 8). The mean duration of each attack was 4.26 days (range, from few hours to 10 d) and the mean interval between the attacks was 1.8 mo (range, 1 wk to 12 mo). The time of onset of the attacks was midnight to early morning in about 70% of cases. Amitriptyline was effective in 46 out of 81 (56%) patients (P < 0.001). Propranolol appeared to have a superior action and was effective in 74 out of 83 (92%) patients (P < 0.0001).CONCLUSION: There is a significant lag time between the onset of clinical symptoms and the final diagnosis of CVS in our area. In patients with typical clinical presentations of CVS, who are examined by an experienced physician, invasive workup is not necessary. Propranolol appears more effective than amitriptyline for prophylactic use in children with CVS. 关 键 词：伊朗南部地区 儿童 周期性呕吐综合征 病例分析 临床经验
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