Effects of IL-4 on cyclooxygenase-2 and platelet-derived growth factor in the lungs of COPD rats

查看全文 作　　者：Yan Li Shengdao Xiong Weining Xiong Yongjian [1]Xu 机构地区：[1]Department of Pulmonary Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 出　　处：《Journal of Nanjing Medical University》索引2007年第21卷第3期,共6页 摘　　要：Objective: To explore the role of interleukin 4(IL-4), expressions of cyclooxygenase-2 (COX-2) and platelet-derived growth factor(PDGF) in the model of chronic obstructive pulmonary disease(COPD), in the lungs of rats. Methods: Male Wistar rats were used to build up the model of COPD. Rats were randomly divided into the control group and model group, the IL-4 group and the dexamethasone group. The expressions of COX-2, PDGF-A and PDGF-B in the lung tissue were detected by western blotting and RT-PCR. Results: The expressions of COX-2, PDGF-A and PDGF-B in the model group were increased significantly. Those expressions in the IL-4 and dexamethasone group were notably decreased. Conclusion: IL-4 and dexamethasone could interfere in the establishment of COPD. The expressions of COX-2 and PDGF in the lung tissue of COPD were increased significantly and IL-4 and dexamethasone could decrease those expressions. 关 键 词：COPD 大鼠 肺脏 白介素-4 环氧化酶-2 血小板衍生生长因子