Expression level of beta-catenin is associated with prognosis of esophageal carcinoma

查看全文 作　　者：Lv Ji Xiu-Feng Cao He-Ming Wang Yi-Sheng Li Bin Zhu Jian Xiao Dan [1]Wang

机构地区：[1]Affillted Nanjing First Hospital, NanjingMedical University, Nanjing 210006, Jiangsu Province, China

出　　处：《World Journal of Gastroenterology》索引2007年第13卷第18期,共4页

摘　　要：AIM: To examine the association of beta-catenin with the clinicopathologic features and prognosis of esophageal squamous cell carcinoma (ESCC). METHODS: Beta-catenin mRNA expression level in 40 ESCC patients (28 males and 12 females, age range 38-82 years, median 60 years) was analyzed by real- time PCR. Beta-catenin mRNA expression levels in tumor cells were categorized as weaker (level 1) or equal to or stronger (level 2) than those in endothelial cells. We examined the correlation between the beta-catenin expression and the clinicopathological factors and prognosis of ESCC patients. RESULTS: Level 2 beta-catenin expression was found in 29 patients. ESCC with level 2 expression had a higher rate of lymphnode metastasis (0.0776 ± 0.0369 vs 0.3413 ± 0.1803, P < 0.001) and deeper tumor invasion (0.0751 ± 0.0356 vs 0.3667 ± 0.1928, P < 0.001), and a poorer survival rate (P = 0.0024) than ESCC with level 1 expression. CONCLUSION: Beta-catenin expression in ESCC is of great importance. 关键词：食道癌 Β-链接素 Β-CATENIN 基因表达水平预后

相关文献

参考文献（20）
引证文献（8）
耦合文献（0）

参考文献(20)

引证文献(8)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Expression level of beta-catenin is associated with prognosis of esophageal carcinoma

参考文献(20)

引证文献(8)

用户提示