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Useful detection of CD147 (EMMPRIN) for pathological diagnosis of early hepatocellular carcinoma in needle biopsy samples

查看全文 作　　者：Satoshi [1]Mamori;Keisuke [1]Nagatsuma;Tomokazu [2]Matsuura;Kiyoshi [3]Ohkawa;Hiroshi [4]Hano;Masaharu [5]Fukunaga;Masato [6]Matsushima;Yoshifumi [1]Masui;Nao [1]Fushiya;Hiroshi [1]Onoda;Yasuyuki [1]Searashi;Ichiro [1]Takagi;Hisao [1]Tajiri 高影响力作者 机构地区：[1]Division of Gastroenterology and Hepatology,Department of Internal Medicine,The Jikei University School of Medicine,Tokyo 105-8461,Japan;[2]Department of Laboratory Medicine,The Jikei University School of Medicine,Tokyo 105-8461,Japan;[3]Department of Biochemistry 1,The Jikei University School of Medicine,Tokyo 105-8461,Japan;[4]Department of Pathology,The Jikei University School of Medicine,Tokyo 105-8461,Japan;[5]Department of Pathology,The Jikei University School of Medicine,The Daisan Hospital,Tokyo 105-8461,Japan;[6]Division of Clinical Research and development,The Jikei University School of Medicine,Tokyo 105-8461,Japan高影响力机构 出　　处：《World Journal of Gastroenterology》索引2007年第13卷第21期,共5页高影响力期刊 摘　　要：AIM:To make clear whether CD147 (EMMPRIN) expression in pathological tumor samples with a fine-needle aspiration biopsy is useful for pathological diagnosis of early hepatocellular carcinoma (HCC). METHODS:Twenty-two patients (15 men and 7 women; median age 68 years,range 56-81 years) underwent a liver tissue biopsy in order to make a diagnosis of HCC. Paraffin-embedded liver biopsy tissue samples from 22 patients were stained with anti-CD147 antibody,murine monoclonal antibody 12C3 (MAb12C3) for immunohistochemical analysis. An immunohistochemical analysis of CD147 was performed and the degree of staining compared between tumor and non-tumor tissue. In addition,the degree of staining within tumor tissue was compared according to a number of clinicopathological variables. RESULTS:The degree of staining of CD147 was significantly higher in tumor tissues than non-tumor tissues,even in tumors less than 15 mm in diameter.The expression of this protein was significantly elevated in HCC tissue specimens from patients with a low value of serum AST and γ-GTP. 关 键 词：CD147 肝癌 早期诊断 病理组织活检
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