The significance of proto-oncogene HGF/SF receptor c-Met mRNA expression in nasopharyngeal carcinoma

查看全文 作　　者：Chongmei [1]Liu;Zhiming [2]Liu;Minzheng [2]Ying;Minghui [1]Lin;Jie [1]Wang;Ming [1]Mao

机构地区：[1]Department of Pathology, Yueyang Second People's Hospital, Yueyang Cancer Hospital of Hunan Province, Yueyang414000, China;[2]Department of Otolaryngology, Yueyang Second People's Hospital, Yueyang Cancer Hospital of Hunan Province, Yueyang 414000, China

出　　处：《The Chinese-German Journal of Clinical Oncology》索引2007年第6卷第3期,共4页

摘　　要：Objective: To explore the expression of c-Met mRNA in nasopharyngeal carcinomas (NPC) and its relation with clinical biological behavior. Methods: In situ hybridisation was used to detect mRNA expression of c-Met in 15 cases of non-tumor nasopharyngeal (NP), 55 cases of NPC. Results: The positive rates of c-Met mRNA in NP and NPC cells were 13.3% (2/15) and 61.8% (34/55) respectively. The expression of c-Met mRNA was significantly correlated with lymph node metastasis, local invasion (skull base erosion), and clinical stage. In cases with cervical lymph node metastasis, local invasion, and clinical stage III and IV (UICC), the positive rates of expression of c-Met mRNA were significantly higher than that in those without the conditions mentioned above (P < 0.05 or P < 0.01). But it was not significantly correlated with age, gender, histo- logic grade, and cranial nerve palsy (P > 0.05). Conclusion: The abnormal expression of c-Met gene was well correlated with the biological behavior of metastasis and invasion. To detection the expression of c-Met mRNA could serve as an important index to estimate the prognosis of NPC. C-Met may be a new diagnostic/therapeutic target of NPC. 关键词：致癌基因肝生长因子鼻咽癌癌细胞转移

相关文献

参考文献（7）
引证文献（7）
耦合文献（27）

参考文献(7)

引证文献(7)

耦合文献(27)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

The significance of proto-oncogene HGF/SF receptor c-Met mRNA expression in nasopharyngeal carcinoma

参考文献(7)

引证文献(7)

耦合文献(27)

用户提示