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Relationship between post-ERCP pancreatitis and the change of serum amylase level after the procedure

查看全文 作  者:Kei [1]Ito;Naotaka [1]Fujita;Yutaka [1]Noda;Go [1]Kobayashi;Jun [1]Horaguchi;Osamu [1]Takasawa;Takashi [1]Obana 高影响力作者 机构地区:[1]Department of Gastroenterology,Sendai City Medical Center,5-22-1,Tsurugaya,Miyagino-ku,Sendai,Miyagi 983-0824,Japan高影响力机构 出  处:《World Journal of Gastroenterology》索引2007年第13卷第28期,共6页高影响力期刊 摘  要:AIM: To clarify the relationship between the change of serum amylase level and post-ERCP pancreatitis. METHODS: Between January 1999 and December 2002, 1291 ERCP-related procedures were performed. Serum amylase concentrations were measured before the procedure and 3, 6, and 24 h afterward. The frequency and severity of post-ERCP pancreatitis and the relationship between these phenomena and the change in amylase level were estimated. RESULTS: Post-ERCP pancreatitis occurred in 47 patients (3.6%). Pancreatitis occurred in 1% of patients with normal amylase levels 3 h after ERCP, and in 1%, 5%, 20%, 31% and 39% of patients with amylase levels elevated 1-2 times, 2-3 times, 3-5 times, 5-10 times and over 10 times the upper normal limit at 3 h after ERCP, respectively (level < 2 times vs ≥ 2 times, P < 0.001). Of the 143 patients with levels higher than the normal limit at 3 h after ERCP followed by elevation at 6 h, pancreatitis occurred in 26%. In contrast, pancreatitis occurred in 9% of 45 patients with a level higher than two times the normal limit at 3 h after ERCP followed by a decrease at 6 h (26% vs 9%, P < 0.05). CONCLUSION: Post-ERCP pancreatitis is frequently associated with an increase in serum amylase level greater than twice the normal limit at 3 h after ERCP with an elevation at 6 h. A decrease in amylase level at 6 h after ERCP suggests the unlikelihood of development of post-ERCP pancreatitis. 关 键 词:急性胰腺炎 内镜逆行胰胆管造影术 血清淀粉酶 血液分析
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