Implications of Cytogenetic Abnormalities and Azoospermia Factor Microdeletions in Assisted Procreation

查看全文 作　　者：Rima [1]Dada;R [1]Kumar;M Bilal [1]Shamsi;Sarabpreet [2]Singh;Col R K [3]Sharma;A [4]Varshney

机构地区：[1]Laboratory of Molecular Reproduction and Genetics, Department of Anatomy,AIIMS, N Delhi, 110029, India;[2]Anatomy Department, AIIMS,N Delhi, 110029, India;[3]ART centre, Obstretics and Gynaecology Department, Army Research and Referral hospital,New Delhi, India;[4]AIIMS,N Delhi, 110029, India

出　　处：《Journal of Reproduction and Contraception》索引2007年第18卷第3期,共5页

摘　　要：Assisted procreation techniques have revolutionized the management of infertility and have offered hope to millions of infertile couples. The main aim of these proce- dures is to produce healthy offspring. However recent studies on short term outcome of ART have reported a higher incidence of low birth weight, development delay, imprinting defects, sex and autosomal structural abnormalities, major and minor congenital malformation and certain cancers in babies conceived via ART. Further the health of ART conceived children beyond the neonatal period have been less well evaluated. A large number of infertile couples opting for ART have an underlying genetic aetiology. These genetic aberrations are iatrogenitically transmitted via ART. Thus it is important that all couples undergo a detailed and comprehensive genetic evaluation prior to ART. 关键词：遗传学染色体变异不育症治疗方法

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Implications of Cytogenetic Abnormalities and Azoospermia Factor Microdeletions in Assisted Procreation

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