维普中文期刊产品整合服务

Antioxidant therapy for chronic hepatitis C after failure of interferon:Results of phase Ⅱ randomized,double-blind placebo controlled clinical trial

查看全文 作　　者：Ezra [1,2]Gabbay;Ehud [1,2]Zigmond;Orit [1,2]Pappo;Nila [1,2]Hemed;Mina [1,2]Rowe;George [3]Zabrecky;Robert [3]Cohen;Yaron [1,2]Ilan 高影响力作者 机构地区：[1]Liver Unit,Department of Medicine;[2]Department of Pathology,Hebrew University,Hadassah Medical Center,Jerusalem IL-91120,Israel;[3]Marcus Foundation,Atlanta,United States高影响力机构 出　　处：《World Journal of Gastroenterology》索引2007年第13卷第40期,共7页高影响力期刊 基　　金：Supported by Markus Foundation 摘　　要：AIM:TO assess the safety and efficacy of antioxidant therapy for patients with chronic hepatitis C virus(HCV) infection. METHODS:One hundred chronic HCV infection patients failed in interferon treatment were enrolled and randomly assigned to receive combined intravenous and oral antioxidants or placebo,or oral treatment alone. Primary end points were liver enzymes,HCV-RNA levels and histology. RESULTS:Combined oral and intravenous antioxidant therapy was associated with a significant decline in ALT levels in 52% of patients who received antioxidant therapy vs 20% of patients who received placebo(P= 0.05).Histology activity index(HAI)score at the end of treatment was reduced in 48% of patients who received antioxidant therapy vs 26% of patients who received placebo(P=0.21).HCV-RNA levels decreased by 1-log or more in 28% of patients who received antioxidant therapy vs 12% who received placebo(P=NS).In partⅡof the trial,oral administration of antioxidants was not associated with significant alterations in any of the end points. CONCLUSION:Antioxidant therapy has a mild beneficial effect on the inflammatory response of chronic HCV infection patients who are non-responders to interferon. Combined antiviral and antioxidant therapy may be beneficial for these patients. 关 键 词：丙型病毒肝炎 抗氧化剂 放射活性 药物治疗
相关文献

参考文献(29)

引证文献(2)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费