Mycophenolate mofetil for drug-induced vanishing bile duct syndrome

查看全文 作　　者：S Simona [1]Jakab;A Brian [2]West;Dennis M [1]Meighan;Robert S Brown [3]Jr;William B [1]Hale

机构地区：[1]Section of Gastroenterology, Norwalk Hospital, Norwalk, CT 06856,United States;[2]Department of Pathology, New York UniversityNew York, NY, United States;[3]Center for Liver Disease and Transplantation, New York-Presbyterian Hospital, Columbia University College of Physicians and Surgeons, New York, NY, United States

出　　处：《World Journal of Gastroenterology》索引2007年第13卷第45期,共3页

摘　　要：Amoxicillin/clavulanate is associated with liver injury, mostly of a cholestatic pattern. While outcomes are usually benign, progression to cirrhosis and death has been reported. The role of immunosuppressive therapy for patients with a protracted course is unclear. We report the case of an elderly patient who developed prolonged cholestasis secondary to amoxicillin/clavulanate. Vanishing bile duct syndrome was confirmed by sequential liver biopsies. The patient responded to prednisone treatment, but could not be weaned off corticosteroids, even when azathioprine was added. Complete withdrawal of both prednisone and azathioprine was possible by using mycophenolate mofetil, an inosine monophosphate dehydrogenase inhibitor. Sustained remission has been maintained for more than 3 years with low-dose mycophenolate mofetil. 关键词：羟氨苄青霉素药物治疗消化道疾病临床表现

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Mycophenolate mofetil for drug-induced vanishing bile duct syndrome

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