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Chemokine system polymorphisms, survival and hepatocellular carcinoma occurrence in patients with hepatitis C virus-related cirrhosis

查看全文 作　　者：Pierre [1]Nahon;Angela [2]Sutton;Pierre [3]Rufat;Chantal [2]Simon;Jean-Claude [1]Trinchet;Liliane [2]Gattegno;Michel [1]Beaugrand;Nathalie [2]Charnaux 高影响力作者 机构地区：[1]Department of Hepatology, Jean Verdier Hospital (AP-HP), Bondy 93140, France;[2]Department of Biochemistry, Jean Verdier Hospital (AP-HP), Bondy 93140, France;[3]Department of Public Health, Pitié-Salpetrière Hospital (AP-HP), Paris 75013, France高影响力机构 出　　处：《World Journal of Gastroenterology》索引2008年第14卷第5期,共7页高影响力期刊 基　　金：the French National Society of Gastro-Enterology and the University Paris XIII 摘　　要：AIM:To explore the influence of polymorphisms in genes encoding for the chemokines Stromal cell-Derived Factor-1 (SDF-1)/CXCL12 and Monocyte Chemotactic Protein-1 (MCP-1)/CCL2 , or for the chemokine receptor CCR5 on the risks of liver-related death and hepatocellular carcinoma (HCC) occurrence in hepatitis C virus (HCV)-infected patients. METHODS:SDF-1 3'A, MCP-1 (-2518) and CCR5-32 polymorphisms, SDF-1α, Regulated upon Activation Normal T cells Expressed and Secreted (RANTES)/CCL5 and MCP-1 serum levels were determined in 120 HCV-infected patients, included at time of cirrhosis diagnosis and prospectively followed-up. RESULTS:During follow-up, 23/120 (19.1%) patients died and 47/120 (39.1%) developed HCC. Carriers and noncarriers of each genetic marker had similar baseline characteristics estimating the severity of liver disease. The occurrence of death or HCC during follow-up was similar among carriers and noncarriers of each polymorphism. There was no association between the carriage of mutated alleles and chemokine serum levels and the latter were not associated with the risks of death or HCC. CONCLUSION:This study suggests the lack of association of SDF-1 3'A , MCP-1 (-2518) , CCR5-32 polymorphisms with death and HCC occurrence in cirrhotic HCV-infected patients. 关 键 词：多态现象 丙肝 肝硬化 患者
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