Natural killer T cells and non-alcoholic fatty liver disease:Fat chews on the immune system

查看全文 作　　者：Michael [1]Kremer;Ian N [2]Hines

机构地区：[1]Department of Surgery, University of Heidelberg, Heidelberg 69120, Germany;[2]Department of Medicine, University of North Carolina at Chapel Hill, CB 7525, United States

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第3期,共2页

摘　　要：Natural killer T cells (NKT) are an important subset of T lymphocytes. They are unique in their ability to produce both T helper 1 and T helper 2 associated cytokines, thus being capable of steering the immune system into either inflammation or tolerance. Disruption of NKT cell numbers or function results in severe deficits in immune surveillance against pathogens and tumor cells. Growing experimental evidence suggests that hepatosteatosis may reduce resident hepatic as well as peripheral NKT cells. Those models of hepatosteatosis and the change in NKT cell numbers are associated with a disruption of cytokine homeostasis, resulting in a more pronounced release of proinflammatory cytokines which renders the steatotic liver highly susceptible to secondary insults. In this letter to the editor, we focus on recently published data in the World Journal of Gastroenterology by Xu and colleagues demonstrating reduced peripheral NKT cells in patients with non-alcoholic fatty liver disease, compare those findings with ours and others in different animal models of hepatosteatosis, and hypothesize about the potential underlying mechanism. 关键词：肥胖症代谢综合症白介素症状

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Natural killer T cells and non-alcoholic fatty liver disease:Fat chews on the immune system

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