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Is acute recurrent pancreatitis a chronic disease?

查看全文 作  者:Alberto [1]Mariani;Pier Alberto [1]Testoni 高影响力作者 机构地区:[1]Division of Gastroen-terology & Gastrointestinal Endoscopy,Vita-Salute San Raffaele University-Scientific Institute San Raffaele,Milan,Italy高影响力机构 出  处:《World Journal of Gastroenterology》索引2008年第14卷第7期,共4页高影响力期刊 摘  要:Whether acute recurrent pancreatitis is a chronic disease is still debated and a consensus is not still reached as demonstrated by differences in the classification of acute recurrent pancreatitis. There is major evidence for considering alcoholic pancreatitis as a chronic disease ab initio while chronic pancreatitis lesions detectable in biliary acute recurrent pancreatitis (ARP) seem a casual association. Cystic fibrosis transmembrane con-ductance regulator (CFTR) gene mutation, hereditary and obstructive pancreatitis seem an acute disease that progress to chronic pancreatitis, likely as a consequence of the activation and proliferation of pancreatic stellate cells that produce and activate collagen and therefore fibrosis. From the diagnostic point of view, in patients with acute recurrent pancreatitis Endoscopic ultrasound (EUS) seems the more reliable technique for an accurate evaluation and follow-up of some ductal and parenchymal abnormalities suspected for early chronic pancreatitis. 关 键 词:胰腺炎 酒精 慢性疾病 急性发作
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