Fine-Tuned Expression of Programmed Death 1 Ligands in Mature Dendritic Cells Stimulated by CD40 Ligand is Critical for the Induction of an Efficient Tumor Specific Immune Response

查看全文 作　　者：Tao [1,2]Gu;Yibei [1,2]Zhu;Cheng [1]Chen;Min [1]Li;Yongjing [1]Chen;Gehua [1]Yu;Yan [1]Ge;Shiyong [1]Zhou;Huan [1]Zhou;Yong [1]Huang;Yuhua [1]Qiu;Xueguang [1]Zhang

机构地区：[1]Medical Biotechnology Institute and Clinical Immunology Laboratory for Jiangsu Province, Soochow University, Suzhou, Jiangsu 215007, China;[2]Tao Gu and Yi-Bei Zhu contributed equally to this work;

出　　处：《Cellular & Molecular Immunology》索引2008年第5卷第1期,共7页

摘　　要：During maturation,murine myeloid dendritic cells (DCs) upregulated the expressions of CD11c,CD25,CD40,CD80,CD86,MHC Ⅱ and programmed death 1 ligands 1 and 2 (PD-L1 and PD-L2). Differential expression patterns of PD-L1 and PD-L2 were found when DCs were triggered by CD40 ligand and TNF-α. PD-L1 expression was repressed and PD-L2 expression remained unchanged in mature CD40-ligated DCs,whereas TNF-α stimulated DCs kept high expression of PD-L1 and significantly enhanced PD-L2 expression on DCs. Proliferations of T lymphocytes stimulated by immature DCs were enhanced by blockade of the PD-1 and PD-1 ligand interaction. But inhibitive effects were found in T lymphocytes stimulated by CD40-ligated DCs. With the fine-tuned expressions of PD-L1 and PD-L2,CD40-ligated DCs could sustain a longer activation period and elicit a more efficient T lymphocyte activation. 关键词：配合基肿瘤免疫系统细胞

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Fine-Tuned Expression of Programmed Death 1 Ligands in Mature Dendritic Cells Stimulated by CD40 Ligand is Critical for the Induction of an Efficient Tumor Specific Immune Response

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