Staging accuracy of esophageal cancer by endoscopic ultrasound:A meta-analysis and systematic review

查看全文 作　　者：Srinivas R [1]Puli;Jyotsna BK [1]Reddy;Matthew L [1]Bechtold;Daphne [1]Antillon;Jamal A [1]Ibdah;Mainor R [1]Antillon

机构地区：[1]Division of Gastroenterology and Hepatology, University of Missouri-Columbia, Columbia, Missouri 65212, United States

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第10期,共12页

摘　　要：AIM: To evaluate the accuracy of endoscopic ultrasound (EUS) in the staging of esophageal cancer. METHODS: Only EUS studies confirmed by surgery were selected. Articles were searched in Medline and Pubmed. Two reviewers independently searched and extracted data. Meta-analysis of the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specificity, likelihood ratios, and diagnostic odds ratio. Pooling was conducted by both the Mantel-Haenszel method (fixed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran’s Q test based upon inverse variance weights. RESULTS: Forty-nine studies (n = 2558) which met the inclusion criteria were included in this analysis. Pooled sensitivity and specificity of EUS to diagnose T1 was 81.6% (95% CI: 77.8-84.9) and 99.4% (95% CI: 99.0-99.7), respectively. To diagnose T4, EUS had a pooled sensitivity of 92.4% (95% CI: 89.2-95.0) and specificity of 97.4% (95% CI: 96.6-98.0). With Fine Needle Aspiration (FNA), sensitivity of EUS to diagnose N stage improved from 84.7% (95% CI: 82.9-86.4) to 96.7% (95% CI: 92.4-98.9). The P value for the χ2 test of heterogeneity for all pooled estimates was > 0.10. CONCLUSION: EUS has excellent sensitivity and specificity in accurately diagnosing the TN stage of esophageal cancer. EUS performs better with advanced (T4) than early (T1) disease. FNA substantially improves the sensitivity and specificity of EUS in evaluating N stage disease. EUS should be strongly considered for staging esophageal cancer. 关键词：食管癌癌症分级内窥镜超声波检查法元分析

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Staging accuracy of esophageal cancer by endoscopic ultrasound:A meta-analysis and systematic review

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