High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis

查看全文 作　　者：Aldo [1]Spadaro;Vincenza [1]Tortorella;Carmela [1]Morace;Agostino [1]Fortiguerra;Paola [1]Composto;Caterina [1]Bonfiglio;Angela [2]Alibrandi;Carmelo [1]Luigiano;Giuseppe De [1]Caro;Antonino [1]Ajello;Oscar [1]Ferraù;Maria Antonietta [1]Freni

机构地区：[1]Department of Medicine and Pharmacology University Hospital, Messina 98125, Italy;[2]Department of Statistics, University oMessina, Messina 98125, Italy

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第10期,共4页

摘　　要：AIM: To measure plasma D-dimer levels in cirrhotic patients with and without ascites, assessing the effect of ascites resolution in D-dimer concentration. METHODS: Seventy consecutive cirrhotic patients (M = 44, F = 26, mean age 65 years, SD ± 13), observed from October 2005 to March 2006 were enrolled. Circulating D-dimer levels were measured using a latex-enhanced, immunoturbidimetric test. In patients with ascites (n = 42) the test was repeated after ascites resolution. RESULTS: Ascites was present in 42 patients (group A) and absent in 28 (group B). Group A patients had more advanced liver disease. Hepatocellular carcinoma (HCC) was diagnosed in 14 patients and was more frequent in group B. Above normal range D-dimers were found in 45/70 patients. High D-dimers were more frequent in group A than in group B (P = 0.001). High D-dimers were associated with presence of HCC (P = 0.048) only in group B. After ascites resolution, obtained in all patients, mean D-dimer values decreased in those 34 patients with high basal levels (P = 0.007), returning to normal in 17. CONCLUSION: In patients with liver cirrhosis, ascites and HCC are the main factors associated with increased fibrinolytic activity. 关键词：肝细胞癌肝硬化腹水 D-二聚物

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High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis

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