Necrotizing enterocolitis: A multifactorial disease with no cure

查看全文 作　　者：Kareena L [1]Schnabl;John E Van [2]Aerde;Alan BR [3]Thomson;Michael T [4]Clandinin

机构地区：[1]Nutrition and Metabolism Research Groups, Department of Medicine, University of Alberta, Edmonton T6G 2P5, Canada;[2]Department of Pediatrics, University of Alberta, Edmonton T6G 2P5, Canada;[3]Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton T6G 2P5, Canada;[4]Alberta Institute for Human Nutrition, University of Alberta, Edmonton T6G 2P5, Canada

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第14期,共20页

基　　金：Canadian Institute of Health research grant, No. 143315,;a National Sciences and Engineering Research Council scholarship 摘　　要：Necrotizing enterocolitis is an inflammatory bowel disease of neonates with significant morbidity and mortality in preterm infants. Due to the multifactorial nature o the disease and limitations in disease models, early diagnosis remains challenging and the pathogenesis elusive. Although preterm birth, hypoxic-ischemic events formula feeding, and abnormal bacteria colonization are established risk factors, the role of genetics and vasoactive/inflammatory mediators is unclear Consequently, treatments do not target the specific underlying disease processes and are symptomatic and surgically invasive. Breast-feeding is the most effective preventative measure. Recent advances in the prevention of necrotizing enterocolitis have focused on bioactive nutrients and trophic factors in human milk. Developmen of new disease models including the aspect of prematurity that consistently predisposes neonates to the disease with multiple risk factors will improve our understanding of the pathogenesis and lead to discovery of innovative therapeutics. 关键词：血管炎症结肠炎致病因素临床表现

相关文献

参考文献（207）
引证文献（23）
耦合文献（31）

参考文献(207)

引证文献(23)

耦合文献(31)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Necrotizing enterocolitis: A multifactorial disease with no cure

参考文献(207)

引证文献(23)

耦合文献(31)

用户提示