Recent Advances in Research on Hepadnaviral Infection in the Woodchuck Model

查看全文 作　　者：Ina [1]Schulte;E-juan [2]ZHANG;Zhong-ji [1]MENG;Rong-juan [1,3]PEI;Mengji [1,2]LU;Michael [1]Roggendorf 机构地区：[1]Institute of Virology, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany;[2]Department of Microbiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan,430030, China;[3]State Key Lab of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan,430071, China 出　　处：《Virologica Sinica》索引2008年第23卷第2期,共9页 基　　金：Deutsche Forschungsgemeinschaft (Lu 669/2-1, GRK1045/1, and Lu 669/5-1) 摘　　要：The woodchuck model is an excellent animal model to study hepadnaviral infection. The new progresses in this model made possible to examine the T-cell mediated immune responses in acute and chronic hepadnaviral infection. Recently, a new assay for cytotoxic T-cells based on detection of CD107 was established for the woodchuck model. In addition, new immunotherapeutic approaches based on combination of potent antiviral treatment and DNA-protein vaccines were proven to be useful for treatment of chronic hepatitis B. 关 键 词：美洲旱獭 细胞 基因 免疫系统