Genome-wide mapping of conserved microRNAs and their host transcripts in Tribolium castaneum

查看全文 作　　者：Qibin [1,2]Luo;Qing [2,3]Zhoub;Xiaomin [2,3]Yu;Hongbin [2,3]Lin;Songnian [1,2]Hu;Jun [1,2]Yu

机构地区：[1]James D. Watson Institute of Genome Sciences, Zhejiang University, Hangzhou 310008, China;[2]Key Laboratory of Genome Information and Sciences, Beijing Institute ofGenomics, ChineseAcademy of Sciences, Beijing 100029, China;[3]Graduated School of the Chinese Academy of Sciences, Beijing 100049, China

出　　处：《Journal of Genetics and Genomics》索引2008年第35卷第6期,共7页

摘　　要：MicroRNAs (miRNAs) are endogenous 22-nt RNAs,which play important regulatory roles by post-transcriptional gene silencing. A computational strategy has been developed for the identification of conserved miRNAs based on features of known metazoan miRNAs in red flour beetle (Tribolium castaneum),which is regarded as one of the major laboratory models of arthropods. Among 118 putative miRNAs,47% and 53% of the predicted miRNAs from the red flour beetle are harbored by known protein-coding genes (intronic) and genes located outside (intergenic miRNA),respectively. There are 31 intronic miRNAs in the same transcriptional orientation as the host genes,which may share RNA polymerase Ⅱ and spliceosomal machinery with their host genes for their biogenesis. A hypothetical feed-back model has been proposed based on the analysis of the relationship between intronic miRNAs and their host genes in the develop-ment of red flour beetle. 关键词：基因组核糖核酸昆虫赤拟谷盗

相关文献

参考文献（48）
引证文献（4）
耦合文献（0）

参考文献(48)

引证文献(4)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Genome-wide mapping of conserved microRNAs and their host transcripts in Tribolium castaneum

参考文献(48)

引证文献(4)

用户提示