Etiopathogenesis of primary sclerosing cholangitis

查看全文 作　　者：Roger [1]Chapman;Sue [1]Cullen

机构地区：[1]Department of Gastroen-terology,John Radcliffe Hospital,Headington,Oxford OX3 9DU,United Kingdom

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第21期,共10页

摘　　要：Primary sclerosing cholangitis(PSC) is a chronic cholestatic liver disease of unknown etiology but lymphocytic portal tract infiltration is suggestive of an immune-mediated basis for this disease.Associations with inflammatory bowel disease(IBD) especially ulcerative colitis(UC),and with particular autoimmune diseases,as well as the genetic associations further suggest PSC may be an immune-mediated disease.The immunogenetics of PSC have been the subject of active research and several HLA and non-HLA associated genes have been implicated in the development of the disease.Lymphocytes derived from the inflamed gut may enter the liver via the enterohepatic circulation to cause hepatic disease.PSC may be triggered in genetically susceptible individuals by infections or toxins entering the portal circulation through a permeable colon and hence evoking an abnormal immune response. 关键词：胆管炎硬化发病机理自身抗体免疫遗传学

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Etiopathogenesis of primary sclerosing cholangitis

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