Is there a place for serum laminin determination in patients with liver disease and cancer?

查看全文 作　　者：Heitor [1]Rosa;Edison Roberto [2]Parise

机构地区：[1]Unit of Gastroenterology and Hepatology,Federal University of Goiás School of Medicine,Goiania,Goiás 74093-080,Brazil;[2]Unity of Hepatology,Federal University of So Paulo(UNIFESP),So Paulo 04024-002,Brazil

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第23期,共5页

摘　　要：Laminin is a glycoprotein which has an important role in the mechanism of fibrogenesis and is,thus,related to hepatic fibrosis in addition to presenting increased levels in several types of neoplasias. However,its determination is not routinely considered in the study of hepatic fibrosis. In this review,the authors critically comment on the role of this glycoprotein compared to other markers of fibrosis through non-invasive procedures(Fibroscan). They also consider its clinical investigational potential and believe that the continuation of these investigations might contribute to a better understanding of the fibrogenic mechanism,which could in turn either lead to the identification of patients at risk of developing fibrosis non-alcoholic fatty liver disease(NAFLD) and non-alcoholic steatohepatitis(NASH) or at least be used as an indicator for hepatic biopsy in such patients. Finally,the authors believe that serum laminin determination might contribute to the diagnosis of epithelial tumor metastasis and peritoneal carcinomatosis. 关键词：肝纤维化肝硬化癌症血清检测

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Is there a place for serum laminin determination in patients with liver disease and cancer?

参考文献(57)

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耦合文献(18)

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