维普中文期刊产品整合服务

Measurement of circulating levels of VEGF-A,-C,and -D and their receptors,VEGFR-1 and -2 in gastric adenocarcinoma

查看全文 作　　者：Mansour S Al-[1]Moundhri;A Al-[2]Shukaili;M Al-[1]Nabhani;B Al-[3]Bahrani;IA [1]Burney;A [1]Rizivi;SS [4]Ganguly 高影响力作者 机构地区：[1]Medical Oncology Unit,Department of Medicine,College of Medicine and Health Sciences,Sultan Qaboos University;[2]Department of Microbiology and Immunology (SQU);[3]National Cancer Institute,Royal Hospital;[4]Department of Epidemiology and Medical Statistics (SQU)高影响力机构 出　　处：《World Journal of Gastroenterology》索引2008年第14卷第24期,共5页高影响力期刊 基　　金：a grant from Sultan Qaboos University Research Fund 摘　　要：AIM: To analyze the serum levels and prognostic significance of vascular endothelial growth factor (VEGF) -A,-C,and -D,and their receptors,VEGFR-1 and -2 in gastric adenocarcinomas. METHODS: The serum levels of VEGF family members were measured in 76 control subjects and 76 patients with gastric adenocarcinoma using an enzyme-linked immunosorbent assay (ELISA). These measurements were correlated with clinco-pathological features and survival rates. RESULTS: The serum levels of VEGF-A and its receptor,VEGFR-1,were signifi cantly higher in patients with gastric cancer than in healthy donors (t = 2.3,P = 0.02 and t = 4.2,P < 0.0001,respectively). In contrast,the serum levels of VEGF-D were signif icantly higher in control subjects than in patients (t = 2.9,P = 0.004). There was no significant difference in serum levels of VEGF-C and VEGFR-2 between patients and controls. VEGF-C was associated with advanced tumor stage and presence of metastasis. VEGFR-1 was associated with metastasis,advanced overall stage,tumor differentiation and survival. VEGFR-2 levels were associated with poor tumor differentiation. There was no significant prognostic value for any of the VEGF family members or their receptors except for VEGFR-1 where high levels were associated with a poor overall survival. CONCLUSION: Serum VEGF levels vary significantly in the same cohort of patients with variable clinico-pathological features and prognostic values. The simultaneous measurement of VEGF receptors levels in sera may overcome the limitations of a single biomarker assay. 关 键 词：胃癌 免疫血清 症状 治疗方法
相关文献

参考文献(12)

引证文献(33)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费